Reaction Kinetic Models of Antibiotic Heteroresistance

Thermodynamically feasible kinetic models of reaction networks.

The dynamics of biological reaction networks are strongly constrained by thermodynamics. An holistic understanding of their behavior and regulation requires mathematical models that observe these constraints. However, kinetic models may easily violate the constraints imposed by the principle of detailed balance, if no special care is taken. Detailed balance demands that in thermodynamic equilib...

Determination of Reaction Kinetic Parameters from Variable Temperature Kinetic Study for Oxidative Addition Reaction on Binuclear Cyclometalated Platinum(II) Complexes

The pseudo-first order rate constants and activation parameters have been determined using two methods, constant-temperature kinetic (CTK) and variable temperature kinetic (VTK), for the oxidative addition reactions of [Pt2Me2(C^N)2(µ-dppf)], (1a, C^N = deprotonated 2-phenylpyridine (ppy); 1b, C^N = deprotonated benzo[h]quinoline (bhq)) with MeI. The results obtained from VTK method are in agre...

Predicting Kinetic Parameters of Acetylene Hydrogenation Reaction Via Optimization Techniques

In this study simulation and optimization of an industrial acetylene hydrogenation reactor was studied. Three well known kinetic models were used for a nearly similar catalyst to predict the industrial data. Due to the complexity of the reactions, none of the offered kinetic models could be considered as an exact kinetic model and it is necessary to determine the kinetic parameters. One of the ...

Mathematical Modeling of Fluorination Reaction of Uranium Dioxide and Evaluation of Existing Gas-Solid Reaction Models

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

In this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in Helicobacter pylori (Hp) eradication, as well as the updated treatment strategies for this infection. The prevalence of antibiotic resistance is increasing all over the world, especially for metronidazole and clarithromycin, because of their heavy use...